Biomedical Sciences Research Center Alexander Fleming (AF)

Infrastructure and Resources:

6a Ioannis Talianidis is an elected member of EMBO. He has been a group leader since 1991 and Institute Director at Fleming since 2006. IT and his team have vast experience in the field of liver development and tissue specific transcription regulation with a strong background in metabolic regulation, chromatin structure studies and microarray-based global analyses. IT has participated in 5 successful EU training networks in the past (ERBCHBGCT920081; HPRN-CT2000 00087, HPMD-CT2000 0002, EST-CT2004 007643, MTKD-CT2005 029610) two of which he was coordinating. Two other senior scientists6b Anna Haroniti (50%) and 6c Iraklis Papageorgiou with expertise in Genomics and Metabolomics (100% of time) will also be involved in the research and the training activities of this program.

Partner Website:

Ioannis Talianidis: http://www.fleming.gr/en/contact.html

Training:

IT has a proven record in training young researchers. In the past 10 years eleven students (including 3 foreign nationals) working in the group received a PhD degree, who continued postdoctoral careers in top US and European labs. Currently the group is training 3 ESRs.

Publications:

1. Boulias K, Katrakili N, Bamberg K, Underhill P, Greenfield A and Talianidis I. (2005) Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP. EMBO J. 24:2624-2633.
2. Hatzis P., Kyrmizi I. and Talianidis I (2006) MAP kinase-mediated disruption of enhancer-promoter communication inhibits HNF4a expression. Mol. Cell. Biol. 19:7017-7029
3. Kyrmizi, I., Hatzis, P., Katrakili, N., Tronche, F., Gonzalez, FJ. and Talianidis I. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20:2293-2305.