De Duve Institute Print

De Duve Institute, Brussels, Belgium

 

 

Infrastructure and Resources:

DDI is associated with the Université Catholique de Louvain Medical School (Brussels) which runs the PhD program in partnership with the inter-university Graduate Colleges of the French Community of Belgium. Research group on "Liver and pancreas development" has specific expertise in molecular and cellular mechanisms of development of the liver and pancreas development and masters techniques in cell and molecular biology, including imaging technology, has access to the facilities of the host institution and runs the transgenic core facility. The group includes 2 PIs, 3 ERs, 4 ESRs, 2 assistants. 2 senior scientists will be involved in training: 2a F Lemaigre (liver development), 2b P Jacquemin (pancreas morphogenesis).

 

Training:

14 PhD theses and 7 post-doctoral researchers have been trained in the group in 1998-2008. Professor Lemaigre is the president of the Graduate School in Biochemistry and Molecular Biology at the Université Catholique de Louvain Medical School (Brussels), and member of the board of the interuniversity Graduate School in Cell and Molecular Biology of the French community of Belgium. Lemaigre lab is a member of FP6 BetaCellTherapy consortium which organizes annual training sessions on cell differentiation and cell therapy.

 

Partner Website:

Frédéric Lemaigre and Patrick Jacquemin:

http://www.deduveinstitute.be/liver_and_pancreas_development.php

 

Publications:

  1. *Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, Roskams T, Rousseau GG, Lemaigre FP (2002) The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development. 129:1819-1828.
  2. Clotman F, Jacquemin P, Plumb-Rudewiez N, Van der Smissen P, Pierreux CE, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP. (2005) Control of liver cell fate decision by a gradient of TGF-beta signaling modulated by Onecut transcription factors. Genes Dev. 19 :1849-1854.
  3. *Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP. (2006) The transcription factor HNF-6 controls the development of pancreatic ducts in the mouse. Gastroenterology. 130:532-541.

* in collaboration with BOLD partners.