UMR7622, CNRS Université Pierre et Marie Curie (UPMC)

Infrastructure and Resources:

The UMR7622 (http://bio-dev.snv.jussieu.fr) is a research unit associated to the UPMC, one of the largest and best French Universities, teaching science and medicine. The UMR7622 is composed of 16 closely interacting research laboratories with expertise on cell-cycle, epigenetics and developmental biology. It has 47 PIs (20 Senior Scientists, 5 Professors, 22 Assistant Professors actively involved in teaching), 12 ERs and 18 ESRs. Cereghini’s lab has specific expertise in molecular mechanisms of early organogenesis in vertebrate embryos and its role in inherited human diseases and is presently a member of the FP6 EuReGene Consortium on Kidney development and diseases. PIs involved in BOLD include  3a Silvia Cereghini (50%), 3b Cécile Haumaitre (70%), 3c Mélanie Paces Fessy (10%), 3d Muriel Umbahuer (5%).

Training:

The lab provides general training on development biology, transcriptional regulation, stem cells, epigenetics, mouse genetics and benefits from local training courses (http://www.ifd.upmc.fr). and meetings in english (shared Meetings of 4-5 UMR 7622 labs with common interests, Journal Clubs, weekly seminars, IFR83 Annual Meetings). It masters techniques in cell and molecular biology, mouse embryology and has access to the facilities of the host institution and the “Institut FederativeIFR83” ( http://ifr-bi.snv.jussieu.fr).

Publications:

1. Lokmane L, Haumaitre C, Garcia-Villalba P, Anselme I, Schneider-Maunoury S, Cereghini S. Critical role of vHNF1/HNF1/TCF2 in vertebrate hepatic specification. Development, 2008. 135(16):2777-86.
2. Haumaitre C, Lenoir O, Scharfmann R. Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol. 2008. 28(20):6373-83.
3. Haumaitre C, Barbacci E, JennyM, Ott MO, Gradwohl G, Cereghini S. Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1490-5.